Wistar igs rat details to scientific products farm, ltd. It is an albino strain, easytohandle, it is however slower learner than long evans rat. Medical images play significant roles in the diagnosis and management of patients. Evaluation of acute and subacute toxicity of pinus. Not all people looking for information on wistar rats are looking for information on lab rats in general, not to mention an image of a dissected one. Wistar rats from different suppliers have a different. Ectopic ucp1 overexpression in white adipose tissue. A statistical analysis of these observations involved 3,400 wistar rats that served as controls in toxicity studies. To develop a metabolic syndrome rat model by induction of fructose drinking water fdw in male wistar rats. Irvingia gabonensis leaves mitigate arsenicinduced renal toxicity in wistar rats. Currently, wistar rats and spraguedawley rats are gradually becoming the most used laboratory animals worldwide. A laboratory rat or lab rat is a rat of the species rattus norvegicus domestica which is bred and kept for scientific research. Toxicology reference data for the wistar rat springerlink. Depending on the parameters of your experiments, cells from wistar rats like wistar rat pbmcs may offer experimental advantages.
Adult female wistar rats were bred in our facilities and fed with purina rat chow, and all animals were killed by cervical dislocation. This study aimed to compare the hypolipidaemic activities of different monascus pigments yellow, red and orange pigments and elucidate their possible regulatory mechanisms on lipid and cholesterol metabolism in rats fed on a highfat diet hfd. Metabolic differences between sprague dawley and wistar. Wistar rats al robai et al, 1993a observed lipolytic effect on the subcutaneous tissue plate 1. Pdf mobile phone usage and male infertility in wistar rats. Pdf in summary, the creation and maintenance of the wistar rats as standardized animals can be attributed to the breeding work of helen. Vaginal cytology pattern and birth features of female wistar.
It is suggested that further studies on the cardiovascular effects of sodium lactate in sh or wistar rats may shed further light on the mechanisms underlying the panicprovoking effect of lactate in panic disorder patients and on the mode of action of antipanic drugs. Dietary apple polyphenols increase skeletal muscle capillaries in wistar rats article pdf available in physiological reports 618 september 2018 with 52 reads how we measure reads. The development of todays laboratory rat has been essentially an american initiative and the great majority of the strains of these animals that are presently in use throughout the scientific world have originated in the usa. There were no dietary factors identified to account for the high incidence of pancreatic proliferative lesions in the present bioassay. Estrus was determined by vaginal smears, and mating was con. Comparison between spraguedawley and wistar rats as an. The fa gene was transferred from the zucker rat m strain to the wistar kyoto wky rat.
Over many years it has become obvious that some conditions and in particular some tumors in rodents have questionable relevance in humans. A humanized rat model of prediabetes by high fat diet. Female wistar rats were given saline vehicle control or nicotine. Melioration of fertility in high fat diet induced obese. Henry h donaldson at the wistar institute in philadelphia. Toxicopathology of paraquat herbicide in female wistar rats author. Fetal and neonatal nicotine exposure in wistar rats causes. Garcialopez p1, perezurizar j, ibarra a, grijalva i, madrazo i, floresmurrieta f, castanedahernandez g, guizarsahagun g. Monascus yellow, red and orange pigments from red yeast. A group of 150 charles river wistar rats 75 of each sex were used in this study. Rodents have been used extensively in virtually all fields of biomedical research and have been the primary species used in toxicologic and carcinogenic research. Depending on the parameters of your experiments, cells from wistar rats, like wistar rat splenocytes, may offer experimental advantages. Files are available under licenses specified on their description page.
Double arrows indicate merged alveoli resulting in airspace enlargement. Agoreyo fo department of physiology, school of basic medical sciences, university of benin, benin city. Nutritional studies on rats fed diets formulated from. Wistar and sd rats were assigned for 2 experimental groups for 17 weeks. The administration of bacterin, like that of crude lipids obtained by the extraction of cell suspension with chloroformmethanol to rats, strain avn wistar, transplanted later with yoshida sarcoma, significantly prolonged the survival of the animals in comparison with the control group. Effects of watermelon citrullus lanatus seed on blood. Recently it was shown that results vary between studies using wistar rats of different suppliers. The wistar rat is one of the two most routinelyused outbred albino rat strains in biomedical research. Thus, overactivity of the hpa system may have blunted the rewarding and locomotor effects of nicotine in wky rats, as observed in the present report. Io rats served as test animals whilethe remaining 10 rats. Miyajima hikari branch, drug safety evaluation laboratories, takeda chemical industries, ltd. While less commonly used for research than mice, rats have served as an important animal model for research in psychology and biomedical science. It is characterized by its wide head, long ears, and a tail length that is always less than its body length. Wistar institute in philadelphia, giving rise to the ubiquitous presentday wistar strain of rats festing, 1979.
In 1960, okamoto at kyoto university selected wistar rats based on the expression of spontaneous hypertension. Buffalo rat norway rat rattus pc12 clone is rattus norvegicus8 rattus norwegicus more. The wistar rat is currently one of the most popular rats used for laboratory research. A hypercaloric pelletdiet cycle induces obesity and comorbidities in wistar rats original an d r e f. Targeted expression of stepfunction opsins in transgenic. Cia was induced in male wistar rats and vagus nerve suspension or sham operation was performed on day 10 after the second immunization. Rats are excellent animal models for experimental neuroscience. Dawley from a hybrid hooded male and a female wistar rat. Pdf combining quantitative and qualitative data in the study of. Nitric oxide induces gelatinase a matrix metalloproteinase 2. Wistar rat splenocytes can be used for a wide variety of immunologybased applications.
Pdf merge combinejoin pdf files online for free soda pdf. Invitro immunoassays, such as elispot, mixed lymphocyte reactions, cytotoxicity assays to measure adcc or cdc, and plaque assays are routinely performed using these cells. In developing countries darkroom radiography is practiced and involves chemical processing of films using chemical substances known to be toxic when ingested or. Male wistar rats 250400 g, male c57bl6 mice 30 g, andmaletask1knockoutkomice30gwereusedin theexperiments. In addition, we tested a source of relatively pure rebaudioside a rebiana, and a consumer version of rebaudioside a truvia.
Effects of aluminium chloride exposure on the cerebral. Toxicopathology of paraquat herbicide in female wistar rats. Photomicrograph of a longitudinal section of wistar rat skin from the control ra t not given fresh leaf extract of calotropis procer a observe the dermis d, a layer of dense fibroelastic tissue with numerous hairfollicles. Efosa g ewere1,2, ngozi p okolie2, gerald i eze3, deborah a jegede1 1department of biochemistry, university of uyo, uyo, nigeria 2department of biochemistry, university of benin, benin, nigeria 3department of anatomy, university of benin, nigeria abstract arsenic has been reported to contaminate groundwater and. At the same time, wistar animals with normal blood pressure were selected to be used as a samegeneticbackground normotensive control of the spontaneously hypertensive rats. The effects of cyfluthrin on some biomarkers in the liver and kidney of wistar rats article pdf available in environmental science and pollution research 226 october 2014 with 155 reads. Aoues 2 1 departement of biotechnology, facult y of sciences, university of mostaganem 27000, algeria. Following the dosing period, the rats were observed for a period of 17 months, after which the surviving animals were sacrificed and necropsied. However, a direct comparison between wistar and spraguedawley sd rat as models of highfat hf dietinduced obesity has not been adequately evaluated so far. The sprague dawley rat and longevans rat were developed from wistar rats. Therefore we studied whether wistar rats obtained from harlan laboratories ha, n 24 and charles river cr, n 22 had a different outcome in an acute myocardial infarction ami model.
Origin and development the wild brown rat rattus norvegicus is thought to have had its original habitat in the temperate areas of what is now the ussr, from the caspian. A hypercaloric pelletdiet cycle induces obesity and co. Nephroprotective effect of sonchus oleraceus extract. For scientific research, male wistar rats rattus norvegicus with an average weight of about 3540 g and 4 to 5 weeks of age were purchased from the animal house laboratory, jahangirnagar university, dhaka, bangladesh. This study aimed to investigate differences in the longterm effects of ovariectomy on these two breeds of rats. Rat pbmcs can be used for a wide variety of immunologybased applications. Wistar rats are more active than others like sprague dawley rats. Albino and hooded or piebald rats are one of the most frequently used laboratory animals for the.
The lowest concentration at which there was a reliable difference in the preference scores of conditioned and control rats was defined as the detection threshold. Pdf cytogenetic effects of lambdacyhalothrin on wistar. Inhibition of the development of collageninduced arthritis. Effects of watermelon citrullus lanatus seed on blood glucose and electrolyte parameters in diabetic wistar rats 1omigie io. Combining quantitative and qualitative data in the study of feeding behavior in male wistar rats. Wistar outbred rats show close genetic similarity with.
Proliferative exocrine pancreatic lesions in aged wistar rats. Pdf protective effect of spirulina platensis on cadmium. Evaluation of acute and subacute toxicity of pinus eldarica bark extract in wistar rats akram ghadirkhomi1, leila safaeian2, behzad zolfaghari3, mohammad reza agha ghazvini4, parisa rezaei5 1. They are also used in immunology as models for infectious diseases and autoimmune responses.
We also compared wistar rats preferences for stevia with the standard noncaloric sweetener saccharin, because. The wistar bloodline has contributed more strains of rats than any other line. Laboratory rats introduction origin and development. In a study carried by qi d et al 2004, adult male wistar rats 270290 g were obtained from the university of british columbia animal care unit and fed a standard laboratory diet pmi feeds, richmond, va and water ad libitum. Feb 10, 2015 a dorsal bilateral adrenalectomy of rat. Genetic architecture of wistar kyoto rat and spontaneously hypertensive rat substrains from different sources yanli zhangjames,1 frank a. The establishment of metabolic syndrome model by induction. Toxic effect of lead on kidney function i n rat wistar f. All animal experiments were approved by the ethics committee of the first hospital of jinlin university in changchun, jilin.
Twentyfour male wistar rats were divided into two groups. Wistar han list of studies wistar han rats species strain sex route vehicle chemical rats wistar han male and female gavage corn oil pentabromodiphenyl ether mixture de71 technical grade rats wistar han male and female gavage corn oil tetrabromobisphenol a rats wistar han male and female gavage water green tea extract rats wistar han. Body weights for all routesvehicles for wistar han rats. Pdf the effects of cyfluthrin on some biomarkers in the. Wistar rat adiposederived mesenchymal stem cells cyagen.
A new experimental model of cigarette smokeinduced emphysema. Materials and methods animals 20 white albino wistar rats weighing between 100 i 50gm were used. Hepatotoxicity and ultra structural changes in wistar rats. A significant decrease in protein kinase c and total sperm count along with increased apoptosis were observed in male wistar rats exposed to mobile phone frequencies 2 hday x 35 days at 0. Pdf hepatic cells and enzymes reactions in wistar rats. Thetask1komicehasbeendescribed in detail elsewhere aller et al. Metabolic syndrome can be caused by modification of diet by means of consumption of high carbohydrate and high fat diet such as fructose. Wistar rat definition of wistar rat by the free dictionary. Then, a series of dilute nacl solutions, ranging from 0. Mobile phone usage and male infertility in wistar rats article pdf available in indian journal of experimental biology 4810. The survey, performed at the 10th generation of backcrossing, showed that wistar fatty rats fafa, a congenic strain of wky, developed obesity and obesityrelated features, such as hyperinsulinemia and hyperlipemia, in the same manner as zucker fatty rats. Ami was induced in both ha and cr wistar rats by one operator.
A similar mechanism to account for the decreased nicotine selfadministration in wky compared to wistar rats has been suggested. Pdf male and female wistar rats differ in decisionmaking. To achieve this objective, al2o3 of three different sizes 30nm, 40nm and bulk was orally administered for 28 days to 9 groups of 10 wistar rats each, at the dose of 500, and 2000 mgkg rat. Biochemical and histopathological profiling of wistar rat.
A tenth group of 10 rats received distilled water and served as control. Its longevity and high rate of spontaneous tumours make it an ideal choice for ageing studies. The common domestic rat, which is found worldwide and is a destructive pest of crops and stored food and a carrier of disease. Steer department of surgery and harvard digestive diseases center, beth israel hospital and haward medical school, boston, masskhusetts the shortterm effects of rat pancreatic duct obstruc tion were evaluated and compared with those re. Comparison between spraguedawley and wistar rats as an experimental model of pharmacokinetic alterations induced by spinal cord injury. They were fed ad libitum on rat cubes ladokun and sons livestock feeds, nigeria limited and allowed free access to fresh clean water in their rat cages. Male and female wistar rats differ in decisionmaking performance in a rodent version of the iowa gambling task article pdf available in behavioural brain research 2342.
Multipotential differentiation ability along osteogenic, chondrogenic and adipogenic lineages. Wistar outbred rats show close genetic similarity with f344 inbred rats satoshi nakanishi1, tadao serikawa1, 2, and takashi kuramoto1 1institute of laboratory animals, graduate school of medicine, kyoto university, yoshidakonoecho, sakyoku. The finding that wky rats showed no deficits in nicotine cta. Cochlear blood flow autoregulation in wistarkyoto rats. The inhand project international harmonization of nomenclature and diagnostic criteria for lesions in rats and mice is a joint initiative of the societies of toxicologic pathology from europe estp, great britain bstp, japan jstp and north america stp to develop an internationallyaccepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. Spontaneous nonthymic t cell lymphomas in young wistar. Wistar rat definition of wistar rat by medical dictionary. However, the application of optogenetics in rats has been hindered because of the limited number of established transgenic rat. In this study, we have investigated the effects of vagus nerve suspension in a rat model of collageninduced arthritis cia.
Global ournal of harmac harmaceutical ciences ie i arile. This study examined the effects of acute exercise on hyperglycemia and kinetic behavior of creatine kinase ck in diabetic rats. If the image photo is included then we should be careful which pages redirect to this article. The wistar rat is an outbred stock, used in all fields of medical and biological research. Prolonged survival of avn wistar rats with transplanted. The wistar rat, wistar hannover wistar han rat, and wistar unilever wu rat are outbred rat strains, while the wistar kyoto and wistar furth rats are inbred strains.
Wistar rat synonyms, wistar rat pronunciation, wistar rat translation, english dictionary definition of wistar rat. Tested negative for bacteria, fungi, and mycoplasma. A strain of albino rat developed at the wistar institute that has spread widely at other institutions. Soda pdf merge tool allows you to combine two or more documents into a single pdf file for free. Wistar rat article about wistar rat by the free dictionary. Learn how to pronounce wistar and more about the wistar word at. Effects of shortterm pancreatic duct obstruction in rats. All structured data from the file and property namespaces is available under the creative commons cc0 license. Henring research, 41 1989 5360 elsevier 53 heares 01247 cochlear blood flow autoregulation in wistar kyoto rats w. Rats were used in research for the first time more than 200 years ago to understand human physiology and medicine 200 years ago, the brown rat, rattus norvegicus, was first used by scientists to understand human physiology and medicine, with early studies concentrating on the effects of food and oxygen deprivation. Vaginal smears prior treatment and during treatment contained epithelial cells consistent with the different phases of estrus in the wistar rat and provided a cyclical pattern indicating that spondias mombin had no negative effect on the estrous cycle of the wistar rat. Wistar kyoto and wistar rats differ in the affective and.
The final study was performed to determine the carcinogenic potential of rotenone delivered by oral gavage. Permeability and distribution of nerve growth factor in the. Cytogenetic effects of lambdacyhalothrin on wistar rat bone marrow. Experimental animals were housed in stainless steel cages with free access to drinking water and diet. In f344n rats, exposure to pyridine resulted in wistar rats, pyridine exposure resulted.
The impact of four different classes of anesthetics on the. In conclusion, we show here that the hfd feeding to weaning wistar rats for 6monthsdeveloped a rat model for prediabetes that showed clinical presentation and pathophysiology of natural history of prediabetes that was found in human. However, the application of optogenetics in rats has been hindered because of the limited number of established transgenic rat strains. The results have been recorded on synoptic charts, which provide frequency distributions, cumulative distributions and variations according to the time of observation, the sex and the age of the rats. He later established wistar institute in philadelphia that will have a major role in the development of the rat as an important laboratory animal similar to the impact the jackson laboratory had on the development of the laboratory mouse.
Genetic architecture of wistarkyoto rat and spontaneously. Ovariectomized spraguedawley sd and wistar rats are widely used as animal models for postmenopausal osteoporosis. They are commonly used in many fields of research, including oncology, aging, pharmacology, toxicology, and metabolismnutrition. Response of creatine kinase ck levels in diabetics wistar rats after acute physical exercise. Are there differences between spraguedawley and wistar. Sep 09, 2012 for example, laboratory rats have smaller adrenals and preputial glands, earlier sexual maturity, no reproductive cycle seasonability, better fecundity and a shorter lifespan than their freeranging wild counterparts. A new genetically obesehyperglycemic rat wistar fatty. Faraone1,2 1department of psychiatry, state university of new york upstate medical university, syracuse, new york. Pdf dietary apple polyphenols increase skeletal muscle.
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